Different to normal protein synthesis, MBP mRNA and ribosomes are transported to the innermost growing layers where translation occurs and sufficient MBP is synthesized to allow compaction to proceed. Schwann cell wrapping itself around axon forming neurilemma. One oligodendrocyte can myelinate up to 40 axons (Pedraza et al. A complex system of channels in the cytoplasm of the extending membrane supports additional membrane trafficking to the growing edge of the myelin sheath (Velumian et al.
#BIO RAD MARKER PROTEIN SERIES#
As the latter continues to encircle the neuron, the membrane also extends laterally along the axon in a series of layers (Figure 3) forming neurilemma. The leading point of this is called the internal mesaxon. One side of the membrane slides underneath the other and continues to wrap itself around the axon. In both scenarios, the structure wraps itself around the axon forming a mesaxon where the membranes make contact. In the CNS, oligodendrocytes extend a plasma membrane structure out to support axons from several neurons. In the PNS, Schwann cells surround the axon, proliferate, and wrap themselves around the axon leaving dispersed gaps termed nodes of Ranvier (Figure 2). Myelination differs between the peripheral nervous system (PNS) and the CNS (Figure 1).
Myelin basic protein (MBP) is a key protein in the functional assembly of the myelin sheath the other proteins of the central nervous system myelin sheath are oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP), the most abundant protein in central nervous system (CNS) myelin. It makes up approximately half of the white matter found in the human brain and occupies about 20% of the space, indicating the importance of myelin in neurotransmission.
Myelin is a sheath that surrounds nerve cells to protect them and enhance signal transmission.
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